Mohn Cancer Research Laboratory was established in 2009 with support from Helse Bergen HF, University of Bergen and Bergen Medical Research Foundation. The foundation has granted 12 MNOK to the laboratory.
Vision: Translational Research
The research, in general, can be characterized as “translational research”, which means that clinical cancer research contributes to laboratory research and vice versa.
The researchers are aiming to reveal the mechanisms regulating the behavior of individual cancers, as well as mechanisms of cancer development and therapy resistance. By doing so, the results may improve therapeutic outcome. (more)
Researchers at the laboratory work with the following issues:
- Somatic mutations that make cancer cells resistant to treatment.
- Germline factors that influence the risk of cancer and result in different clinical expressions and different degrees of side effects during treatment.
- Hormones and their role in cancer development and treatment of various hormone-sensitive cancers.
Research is mainly focused on cancer arising in the breast, ovaries, testes, prostate and the gastrointestinal tract as well as on malignant melanomas. (more)
In general, the aim of the analyses is to identify genetic mutations, epigenetic changes, and deregulation of gene expression relevant to cancer risk or to treatment efficacy in established cancer. Such “screening analyses” are carried out using methods like PCR with subsequent Sanger sequencing, quantitative PCR (real-time PCR), bisulfite modification of DNA with subsequent methylation-specific analysis, MLPA, Fluorescence in situ hybridization (FISH) and immunohistochemistry performed on tissue microarrays. All findings are related to updated clinical databases. (more)
There is a close collaboration between clinicians, engineers, PhD students, postdoctoral fellows and professors.
There is also collaboration between several departments and divisions related to both Haukeland University Hospital and the University of Bergen (Division of Oncology and Division of Endocrinology, Department of Medicine, Division of Oncology and Medical Physics, Department of Surgical Sciences, Department of Gynecology, Department of Clinical Medicine and Center for Medical Genetics and Molecular Medicine).
This constitutes a unique basis for synergy and for utilizing the expertise that exists in Bergen within this field.
In addition, there is established cooperation with several national and international research groups. (more)
The laboratory was officially opened on December 21th, 2009 in the new Laboratory Building at Haukeland University Hospital. It consists of 300 m2 with new and modern instruments and in addition to areas of Section of Oncology (University of Bergen).